Hong-Zhuan Chen Selected Research

Neuroinflammatory Diseases

1/2021	Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model.
11/2009	Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice.

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Hong-Zhuan Chen Research Topics

Disease

52	Neoplasms (Cancer) 01/2024 - 01/2006
21	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 07/2003
11	Neoplasm Metastasis (Metastasis) 01/2024 - 01/2014
8	Cognitive Dysfunction 01/2023 - 12/2005
7	Adenocarcinoma of Lung 01/2023 - 01/2018
7	Glaucoma 02/2021 - 02/2006
5	Memory Disorders (Memory Loss) 08/2021 - 07/2003
5	Ischemia 02/2021 - 07/2005
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 09/2016
4	Lung Neoplasms (Lung Cancer) 10/2021 - 09/2017
4	Glioblastoma (Glioblastoma Multiforme) 01/2019 - 05/2015
4	Inflammation (Inflammations) 09/2017 - 04/2008
3	Melanoma (Melanoma, Malignant) 01/2024 - 03/2014
3	Breast Neoplasms (Breast Cancer) 01/2022 - 03/2010
3	Colorectal Neoplasms (Colorectal Cancer) 06/2021 - 01/2014
3	Pathologic Processes 01/2019 - 01/2016
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2019 - 01/2015
3	Hypoxia (Hypoxemia) 08/2018 - 01/2017
3	Glioma (Gliomas) 02/2013 - 09/2002
3	Brain Ischemia (Cerebral Ischemia) 09/2012 - 01/2004
2	Triple Negative Breast Neoplasms 01/2024 - 09/2021
2	Infections 01/2023 - 04/2022
2	COVID-19 04/2022 - 03/2021
2	Stomach Neoplasms (Stomach Cancer) 11/2021 - 10/2018
2	Gallbladder Neoplasms (Gallbladder Cancer) 08/2021 - 11/2019
2	Neuroinflammatory Diseases 01/2021 - 11/2009
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2006
2	Dementia (Dementias) 05/2020 - 02/2014
2	Adenocarcinoma 09/2017 - 08/2013
2	Pneumonia (Pneumonitis) 01/2016 - 11/2012
2	Necrosis 02/2015 - 03/2010
2	Asthma (Bronchial Asthma) 06/2013 - 02/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2012 - 07/2005
2	Sialorrhea 12/2009 - 07/2003

Drug/Important Bio-Agent (IBA)

9	Peptides (Polypeptides)IBA 01/2024 - 11/2003
8	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2023 - 01/2018
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2003
7	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 05/2020 - 04/2008
6	EnzymesIBA 10/2022 - 01/2018
6	Angiogenesis InhibitorsIBA 01/2016 - 03/2010
5	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 01/2004
5	Amyloid (Amyloid Fibrils)IBA 08/2021 - 11/2003
5	LigandsIBA 09/2016 - 11/2009
5	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 03/2010
4	Oxygen (Dioxygen)IBA 10/2023 - 01/2004
4	ErbB Receptors (EGF Receptor)IBA 01/2023 - 01/2018
4	Phosphoglycerate Mutase (Phosphoglyceromutase)IBA 01/2023 - 12/2019
4	Neuroprotective AgentsIBA 02/2021 - 09/2009
4	satropaneIBA 01/2017 - 11/2008
3	Interleukin-6 (Interleukin 6)IBA 01/2023 - 11/2012
3	HKB99IBA 01/2023 - 12/2019
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 01/2019
3	Aldehyde DehydrogenaseIBA 01/2023 - 09/2017
3	Tyrosine Kinase InhibitorsIBA 10/2021 - 01/2018
3	Retinaldehyde (Retinal)IBA 02/2021 - 03/2014
3	Indicators and Reagents (Reagents)IBA 01/2021 - 10/2018
3	CytokinesIBA 10/2019 - 06/2013
3	SteroidsIBA 01/2019 - 01/2015
3	Small Interfering RNA (siRNA)IBA 08/2018 - 10/2017
3	RNA (Ribonucleic Acid)IBA 01/2018 - 09/2017
3	Pilocarpine (Ocusert)FDA LinkGeneric 03/2014 - 07/2003
3	Scopolamine (Hyoscine)FDA Link 02/2014 - 07/2003
3	Cholinergic Agents (Cholinergics)IBA 02/2014 - 07/2003
3	Muscarinic AgonistsIBA 08/2013 - 07/2003
3	Desipramine (Pertofrane)FDA LinkGeneric 02/2013 - 09/2002
3	Antidepressive Agents (Antidepressants)IBA 02/2013 - 09/2009
2	Amino Acids FDA Link 10/2023 - 01/2019
2	TOR Serine-Threonine KinasesIBA 01/2023 - 07/2015
2	osimertinibIBA 01/2023 - 12/2019
2	AcidsIBA 03/2022 - 04/2008
2	Oxidoreductases (Dehydrogenase)IBA 11/2021 - 08/2018
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 09/2021 - 01/2021
2	Photosensitizing Agents (Photosensitizers)IBA 09/2021 - 08/2018
2	Long Noncoding RNAIBA 08/2021 - 11/2019
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2021 - 01/2021
2	asparaginylendopeptidase (legumain)IBA 08/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 08/2021 - 01/2019
2	huperzine AIBA 02/2021 - 04/2009
2	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 01/2021 - 01/2018
2	Lipoproteins (Lipoprotein)IBA 02/2020 - 10/2017
2	Gefitinib (Iressa)FDA Link 12/2019 - 09/2017
2	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 01/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 01/2006
2	ApolipoproteinsIBA 10/2017 - 12/2016
2	HDL LipoproteinsIBA 10/2017 - 12/2016
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2017 - 01/2006
2	Apolipoproteins E (ApoE)IBA 01/2016 - 01/2015
2	Nanoparticle Drug Delivery SystemIBA 08/2015 - 03/2014
2	TriterpenesIBA 01/2015 - 02/2013
2	Caspase 3 (Caspase-3)IBA 03/2014 - 09/2002
2	Docetaxel (Taxotere)FDA Link 03/2014 - 05/2013
2	OvalbuminIBA 06/2013 - 02/2011
2	anisodamineIBA 07/2012 - 02/2011
2	Amyloid beta-PeptidesIBA 11/2009 - 11/2003
2	Single-Chain AntibodiesIBA 04/2009 - 03/2008

Therapy/Procedure

35	Therapeutics 10/2023 - 07/2005
11	Drug Therapy (Chemotherapy) 01/2023 - 03/2010
4	Immunotherapy 01/2024 - 03/2008
3	Photochemotherapy (Photodynamic Therapy) 09/2021 - 08/2018
2	Combination Drug Therapy (Combination Chemotherapy) 01/2016 - 02/2011